Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae
Cornick, Jennifer E. and Chaguza, Chrispin and Harris, Simon R. and Yalcin, Feyruz and Senghore, Madikay and Kiran, Anmol M. and Govindpershad, Shanil and Ousmane, Sani and Plessis, Mignon Du and Pluschke, Gerd and Ebruke, Chinelo and McGee, Lesley and Sigaùque, Beutel and Collard, Jean-Marc and Antonio, Martin and von Gottberg, Anne and French, Neil and Klugman, Keith P. and Heyderman, Robert S. and Bentley, Stephen D. and Everett, Dean B. and for the PAGe Consortium,, 1, e000027 (2015),
doi = https://doi.org/10.1099/mgen.0.000027,
publicationName = Microbiology Society,
issn = ,
abstract= Serotype 1 Streptococcus pneumoniae is a leading cause of invasive pneumococcal disease (IPD) worldwide, with the highest burden in developing countries. We report the whole-genome sequencing analysis of 448 serotype 1 isolates from 27 countries worldwide (including 11 in Africa). The global serotype 1 population shows a strong phylogeographic structure at the continental level, and within Africa there is further region-specific structure. Our results demonstrate that region-specific diversification within Africa has been driven by limited cross-region transfer events, genetic recombination and antimicrobial selective pressure. Clonal replacement of the dominant serotype 1 clones circulating within regions is uncommon; however, here we report on the accessory gene content that has contributed to a rare clonal replacement event of ST3081 with ST618 as the dominant cause of IPD in the Gambia.,
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