An untypeable enterotoxigenic Escherichia coli represents one of the dominant types causing human disease
Iguchi, Atsushi and von Mentzer, Astrid and Kikuchi, Taisei and Thomson, Nicholas R.,, 3, e000121 (2017),
doi = https://doi.org/10.1099/mgen.0.000121,
publicationName = Microbiology Society,
issn = ,
abstract= doi: 10.1099/mgen.0.000121.001. Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea in children below 5 years of age in endemic areas, and is a primary cause of diarrhoea in travellers visiting developing countries. Epidemiological analysis of E. coli pathovars is traditionally carried out based on the results of serotyping. However, genomic analysis of a global ETEC collection of 362 isolates taken from patients revealed nine novel O-antigen biosynthesis gene clusters that were previously unrecognized, and have collectively been called unclassified. When put in the context of all isolates sequenced, one of the novel O-genotypes, OgN5, was found to be the second most common ETEC O-genotype causing disease, after O6, in a globally representative ETEC collection. It’s also clear that ETEC OgN5 isolates have spread globally. These novel O-genotypes have now been included in our comprehensive O-genotyping scheme, and can be detected using a PCR-based and an in silico typing method. This will assist in epidemiological studies, as well as in ETEC vaccine development.,
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