Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis
Lilje, Berit and Rasmussen, Rasmus Vedby and Dahl, Anders and Stegger, Marc and Skov, Robert Leo and Fowler, Vance G. and Ng, Kim Lee and Kiil, Kristoffer and Larsen, Anders Rhod and Petersen, Andreas and Johansen, Helle Krogh and Schønheyder, Henrik Carl and Arpi, Magnus and Rosenvinge, Flemming S. and Korup, Eva and Høst, Ulla and Hassager, Christian and Gill, Sabine Ute Alice and Hansen, Thomas Fritz and Johannesen, Thor Bech and Smit, Jesper and Søgaard, Peter and Skytt Andersen, Paal and Eske-Bruun, Niels,, 3, e000138 (2017),
doi = https://doi.org/10.1099/mgen.0.000138,
publicationName = Microbiology Society,
issn = ,
abstract= Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia.,
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