RT Journal Article SR Electronic(1) A1 Lilje, Berit A1 Rasmussen, Rasmus Vedby A1 Dahl, Anders A1 Stegger, Marc A1 Skov, Robert Leo A1 Fowler, Vance G. A1 Ng, Kim Lee A1 Kiil, Kristoffer A1 Larsen, Anders Rhod A1 Petersen, Andreas A1 Johansen, Helle Krogh A1 Schønheyder, Henrik Carl A1 Arpi, Magnus A1 Rosenvinge, Flemming S. A1 Korup, Eva A1 Høst, Ulla A1 Hassager, Christian A1 Gill, Sabine Ute Alice A1 Hansen, Thomas Fritz A1 Johannesen, Thor Bech A1 Smit, Jesper A1 Søgaard, Peter A1 Skytt Andersen, Paal A1 Eske-Bruun, NielsYR 2017 T1 Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis JF Microbial Genomics, VO 3 IS 11 OP SP e000138 DO https://doi.org/10.1099/mgen.0.000138 PB Microbiology Society, SN 2057-5858, AB Most Staphylococcus aureus isolates can cause invasive disease given the right circumstances, but it is unknown if some isolates are more likely to cause severe infections than others. S. aureus bloodstream isolates from 120 patients with definite infective endocarditis and 121 with S. aureus bacteraemia without infective endocarditis underwent whole-genome sequencing. Genome-wide association analysis was performed using a variety of bioinformatics approaches including SNP analysis, accessory genome analysis and k-mer based analysis. Core and accessory genome analyses found no association with either of the two clinical groups. In this study, the genome sequences of S. aureus bloodstream isolates did not discriminate between bacteraemia and infective endocarditis. Based on our study and the current literature, it is not convincing that a specific S. aureus genotype is clearly associated to infective endocarditis in patients with S. aureus bacteraemia., UL https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000138