@article{mbs:/content/journal/mgen/10.1099/mgen.0.000168, author = "Almpanis, Apostolos and Swain, Martin and Gatherer, Derek and McEwan, Neil", title = "Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages", journal= "Microbial Genomics", year = "2018", volume = "4", number = "4", pages = "", doi = "https://doi.org/10.1099/mgen.0.000168", url = "https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000168", publisher = "Microbiology Society", issn = "2057-5858", type = "Journal Article", keywords = "bacteria", keywords = "genome G+C content", keywords = "genome length", keywords = "plasmids", eid = "e000168", abstract = "Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.", }