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Volume 169, Issue 12

Interbacterial competition mediated by the type VIIb secretion system Open Access

This article is part of the Bacterial Competitive Mechanisms collection.

Abstract

Successful occupancy of a given niche requires the colonising bacteria to interact extensively with the biotic and abiotic environment, including other resident microbes. Bacteria have evolved a range of protein secretion machines for this purpose with eleven such systems identified to date. The type VIIb secretion system (T7SSb) is utilised by Bacillota to secrete a range of protein substrates, including antibacterial toxins targeting closely related strains, and the system as a whole has been implicated in a range of activities such as iron acquisition, intercellular signalling, host colonisation and virulence. This review covers the components and secretion mechanism of the T7SSb, the substrates of these systems and their roles in Gram-positive bacteria, with a focus on interbacterial competition.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): bacterial competition , contact-dependent inhibition , protein secretion , T7SS , toxin and type VII secretion system
Funding
This study was supported by the:
  • Wellcome Trust (Award 224151/Z/21/Z)
    • Principle Award Recipient: TracyPalmer
  • Wellcome Trust (Award 10183/Z/15/Z)
    • Principle Award Recipient: TracyPalmer
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-05-08
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/mic.0.001420
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Interbacterial competition mediated by the type VIIb secretion system
Microbiology 169, 001420 (2023); https://doi.org/10.1099/mic.0.001420
/content/journal/micro/10.1099/mic.0.001420
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