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Volume 6, Issue 1

Using genomics to understand meticillin- and vancomycin-resistant infections Open Access

Abstract

Resistance to meticillin and vancomycin in significantly complicates the management of severe infections like bacteraemia, endocarditis or osteomyelitis. Here, we review the molecular mechanisms and genomic epidemiology of resistance to these agents, with a focus on how genomics has provided insights into the emergence and evolution of major meticillin-resistant clones. We also provide insights on the use of bacterial whole-genome sequencing to inform management of infections and for control of transmission at the hospital and in the community.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antibiotic resistance , genomics , MRSA , Staphylococcus aureus and vancomycin
Funding
This study was supported by the:
  • National Health and Medical Research Council (Award 1123854)
    • Principle Award Recipient: Deborah A. Williamson
  • National Health and Medical Research Council (Award 1145033)
    • Principle Award Recipient: Steven Y. C. Tong
© 2020 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2020-01-08
2024-04-19
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http://instance.metastore.ingenta.com/content/journal/mgen/10.1099/mgen.0.000324
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Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections
M Gen 6, e000324 (2020); https://doi.org/10.1099/mgen.0.000324
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