%0 Journal Article %A Cornick, Jennifer E. %A Chaguza, Chrispin %A Harris, Simon R. %A Yalcin, Feyruz %A Senghore, Madikay %A Kiran, Anmol M. %A Govindpershad, Shanil %A Ousmane, Sani %A Plessis, Mignon Du %A Pluschke, Gerd %A Ebruke, Chinelo %A McGee, Lesley %A SigaĆ¹que, Beutel %A Collard, Jean-Marc %A Antonio, Martin %A von Gottberg, Anne %A French, Neil %A Klugman, Keith P. %A Heyderman, Robert S. %A Bentley, Stephen D. %A Everett, Dean B. %A for the PAGe Consortium %T Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae %D 2015 %J Microbial Genomics, %V 1 %N 2 %@ 2057-5858 %C e000027 %R https://doi.org/10.1099/mgen.0.000027 %K Genomics %K Pneumococcal Disease %K Africa %K Phylogeny %K PAGe %K Antibiotic Resistance %K Recombination %I Microbiology Society, %X Serotype 1 Streptococcus pneumoniae is a leading cause of invasive pneumococcal disease (IPD) worldwide, with the highest burden in developing countries. We report the whole-genome sequencing analysis of 448 serotype 1 isolates from 27 countries worldwide (including 11 in Africa). The global serotype 1 population shows a strong phylogeographic structure at the continental level, and within Africa there is further region-specific structure. Our results demonstrate that region-specific diversification within Africa has been driven by limited cross-region transfer events, genetic recombination and antimicrobial selective pressure. Clonal replacement of the dominant serotype 1 clones circulating within regions is uncommon; however, here we report on the accessory gene content that has contributed to a rare clonal replacement event of ST3081 with ST618 as the dominant cause of IPD in the Gambia. %U https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000027