RT Journal Article SR Electronic(1) A1 Dallman, Tim A1 Inns, Thomas A1 Jombart, Thibaut A1 Ashton, Philip A1 Loman, Nicolas A1 Chatt, Carol A1 Messelhaeusser, Ute A1 Rabsch, Wolfgang A1 Simon, Sandra A1 Nikisins, Sergejs A1 Bernard, Helen A1 le Hello, Simon A1 Jourdan da-Silva, Nathalie A1 Kornschober, Christian A1 Mossong, Joel A1 Hawkey, Peter A1 de Pinna, Elizabeth A1 Grant, Kathie A1 Cleary, PaulYR 2016 T1 Phylogenetic structure of European Salmonella Enteritidis outbreak correlates with national and international egg distribution network JF Microbial Genomics, VO 2 IS 8 OP SP e000070 DO https://doi.org/10.1099/mgen.0.000070 PB Microbiology Society, SN 2057-5858, AB Outbreaks of Salmonella Enteritidis have long been associated with contaminated poultry and eggs. In the summer of 2014 a large multi-national outbreak of Salmonella Enteritidis phage type 14b occurred with over 350 cases reported in the United Kingdom, Germany, Austria, France and Luxembourg. Egg supply network investigation and microbiological sampling identified the source to be a Bavarian egg producer. As part of the international investigation into the outbreak, over 400 isolates were sequenced including isolates from cases, implicated UK premises and eggs from the suspected source producer. We were able to show a clear statistical correlation between the topology of the UK egg distribution network and the phylogenetic network of outbreak isolates. This correlation can most plausibly be explained by different parts of the egg distribution network being supplied by eggs solely from independent premises of the Bavarian egg producer (Company X). Microbiological sampling from the source premises, traceback information and information on the interventions carried out at the egg production premises all supported this conclusion. The level of insight into the outbreak epidemiology provided by whole-genome sequencing (WGS) would not have been possible using traditional microbial typing methods., UL https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000070